Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells?
نویسندگان
چکیده
منابع مشابه
Pacemaker Synchronization of Electrically Coupled Rabbit Sinoatrial Node Cells
The effects of intercellular coupling conductance on the activity of two electrically coupled isolated rabbit sinoatrial nodal cells were investigated. A computer-controlled version of the "coupling clamp" technique was used in which isolated sinoatrial nodal cells, not physically in contact with each other, were electrically coupled at various values of ohmic coupling conductance, mimicking th...
متن کاملFactors controlling pacemaker action in cells of the sinoatrial node.
• Studies of the effects of imposed drive on isolated mammalian sinoatrial (SA) node pacemaker cells were undertaken as a result of the observed effects of rapid drive imposed on in situ pacemakers. Such studies are not new since Gaskell in 1884 observed that tetanic stimulation of the turtle sinus venosus or atria had an inhibitory effect on pacemaker function. In the most recent studies of th...
متن کاملThe sinoatrial node, a heterogeneous pacemaker structure.
This article focuses on the regional heterogeneity of the mammalian sinoatrial (SA) node in terms of cell morphology, pacemaker activity, action potential configuration and conduction, densities of ionic currents (i(Na), i(Ca,L), i(to), i(K,r), i(K,s) and i(f)), expression of gap junction proteins (Cx40, Cx43 and Cx45), autonomic regulation, and ageing. Experimental studies on the single SA nod...
متن کاملSCN5A and sinoatrial node pacemaker function.
The SCN5A gene encodes specific voltage-dependent Na+ channels abundant in cardiac muscle that open and close at specific stages of cardiac activity in response to voltage change, thereby controlling the magnitude and timecourse of voltage-dependent Na+ currents (iNa) in cardiac muscle cells. Although iNa has been recorded from sinoatrial (SA) node pacemaker cells, its precise role in SA node p...
متن کاملPhase response characteristics of sinoatrial node cells
In this work, the dynamic response of the sinoatrial node (SAN), the natural pacemaker of the heart, to short external stimuli is investigated using the Zhang et al. model. The model equations are solved twice for the central cell and for the peripheral cell. A short current pulse is applied to reset the spontaneous rhythmic activity of the single sinoatrial node cell. Depending on the stimulus...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2021
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-021-00827-w